Sept. 19, 2026, 7:01 a.m. ET
The 2026 NFL season is formally underway, and Week 1 delivered no scarcity of surprises, assertion performances and dramatic finishes. Now consideration turns to Week 2, the place one other full slate of video games provides loads of alternatives for bettors.
The USA TODAY Sports activities NFL workers is again to interrupt down the perfect bets for Sunday. After going 2-3 in Week 1, our consultants want to bounce again with a stronger displaying in Week 2.
With 14 video games on Sunday’s Week 2 slate, bettors have loads of markets to select from. Our crew of NFL consultants has narrowed down the perfect alternatives throughout spreads, totals, participant props and anytime landing markets.
Every choose comes with an in-depth breakdown of the matchup and the reasoning behind the wager. Whether or not you are in search of a aspect, whole or participant prop, our consultants have you ever lined.
Listed below are our greatest NFL bets for Sunday’s Week 2 video games. Better of luck when you tail!
Greatest bets NFL Week 2
All odds listed are supplied by DraftKings Sportsbook. Entry USA TODAY Sports activities Scores and Sports activities Betting Odds hub for a whole record.
Taking part analysts: Nick Brinkerhoff, Jack McKessy, Jacob Camenker, Adam Kaufman, Tom Viera
Vikings WR Justin Jefferson anytime TD vs. Bears (+160)
Nick Brinkerhoff: It’s a story as previous as time. Screw up, then overcorrect to make issues proper. Neglect to take the rooster out of the freezer? That received’t occur subsequent time. Your boss has an perspective in a gathering and ticks everybody off? There’s a 100% probability they present as much as the subsequent one pretending all the pieces is all sunshine and rainbows. Neglect a present? Time to purchase further.
The identical is true of Jefferson with the Vikings, who was saddled with horrific quarterback play in 2025. To maintain arguably the perfect receiver within the sport comfortable, the Vikings tossed him a pair of touchdowns in Week 1. And that was after Kyler Murray exited with a concussion. Eight catches for 92 yards isn’t a nasty day on the workplace and it simply goes to indicate how quarterback-proof Jefferson is when Minnesota is definitely enjoying one – sorry, J.J. McCarthy.
Chicago turned out to be a bettor’s dream in opening week, cleansing up the anytime landing board in a method that we haven’t seen for the reason that well-known Rams-Chiefs contest on “Monday Night time Soccer” in 2018. Jefferson ought to be a lot busy towards the Bears, who would reasonably rating factors on offense than try to forestall them on protection. We’re getting a pleasant worth for that overcorrection to proceed from Kevin O’Connell. And we’ll be “Griddying” all the way in which to the financial institution when it does.
Chiefs RB Kenneth Walker III to complete with 100+ speeding yards (+216)
Jack McKessy: The Chiefs made it very obvious in Week 1 that their new offensive id – at the very least to start out the season – in 2026 is constructed round quarterback Patrick Mahomes lining up below middle and handing the ball to the reigning Tremendous Bowl MVP. Kansas Metropolis pounded the rock towards the Broncos in Week 1, letting Walker cook dinner to the tune of a career-best 173 yards and a landing on 23 carries – averaging 7.5 yards per carry.
The Colts‘ protection is a (a lot) worse unit than the Broncos’ on paper. Final week, Indianapolis allowed Ravens veteran operating again Derrick Henry to hurry for 144 yards and three scores on 24 carries (6.0 yards per carry) in a house loss. The Colts lack the defensive personnel to succeed up entrance towards the Chiefs’ hog-mollies, nor have they got the second-level defenders to reliably take down Walker if he breaks one open. Add in Mahomes’ early-season rustiness in getting back from his knee damage, and Week 2’s “Sunday Night time Soccer” sport appears a recipe for a second straight large sport from the Chiefs’ new lead again.
Browns RB Quinshon Judkins UNDER 48.5 speeding yards (-114)
Jacob Camenker: Look, I do know it is by no means enjoyable to wager the below, however backing Judkins appears unimaginable so long as Deshaun Watson stays Cleveland’s starter. Groups will seemingly key in on stopping the run and forcing Watson, who has an 81.3 passer score since becoming a member of the Browns in 2022, to beat them, which does not bode properly for Judkins regardless of his high-volume position in Cleveland’s skinny backfield.
Additional dampening Judkins’ upside is his matchup with the Buccaneers. Tampa Bay has lengthy been good towards the run due to Vita Vea, and the crew’s 60 speeding yards allowed to operating backs in Week 1 towards the Bengals had been the seventh-fewest league-wide. Perhaps Judkins will break one long term to render this moot, however his 3.6 profession yards-per-carry common makes that unlikely to occur.
Buccaneers QB Baker Mayfield OVER 204.5 passing yards (-114)
Adam Kaufman: I do not get it. Is that this a first-half line?
Baker Mayfield’s had this sport circled on his calendar, most likely for years. The previous Browns’ No. 1 choose had some success in Cleveland – at the very least by that group’s requirements – after which possession give up on its QB in favor of embattled then-star Deshaun Watson to the tune of $230 million assured.
Similar to that, bye-bye Baker. Then got here the Panthers. And Rams.
Lastly, the journeyman discovered a brand new residence in Tampa because the Buccaneers’ franchise quarterback, successful a number of division titles and incomes Professional Bowler honors twice.
One identified to carry a grudge, Mayfield now will get to face his previous crew, with an opportunity to beat the Browns for the primary time. With Watson on the opposite aspect.
This one’s private. Mayfield will depart all of it on the sector. We’re simply alongside for the trip.
49ers WR Mike Evans anytime TD vs Dolphins (+130)
Tom Viera: Sadly, Omarion Hampton allow us to all the way down to open the season; after scoring as soon as within the first quarter, the Chargers’ offense forgot they’d three extra quarters to play. Luckily, we now have 17 extra weeks to get our lick again, and the landing practice goes to an ole’ dependable for Week 2.
Mike Evans will get a Miami Dolphins protection subsequent and Kyle Shanahan and co. have to be licking their chops. The veteran instantly established himself as a focus of San Francisco’s passing sport, main the 49ers in targets with seven in his debut. Evans caught six of these for 49 yards and located the tip zone on a two-yard landing from Brock Purdy, displaying the quarterback already trusts him down within the crimson zone.
The matchup ought to solely add to the attraction. Miami’s younger, inexperienced secondary struggled towards Las Vegas in Week 1, permitting Kirk Cousins to throw three landing passes. Cousins was working with a group of weapons that does not examine to Evans’ mixture of measurement, expertise, red-zone dominance and sheer observe file.
San Francisco has additionally ranked among the many NFL’s best red-zone passing offenses in latest seasons (third within the NFL in red-zone passing touchdowns), whereas Evans has constantly been among the many league leaders in end-zone targets. 5 of Evans’ six catches towards the Rams got here on third down, one other encouraging signal of the belief already creating between him and Purdy. In opposition to Miami, anticipate that connection to supply one other journey to the tip zone.
Greatest bets total information:
- Nick Brinkerhoff: 0-1 (-1.0 Unit)
- Jack McKessy: 1-0 (+1.0 Models)
- Jacob Camenker: 1-0 (+2.45 Models)
- Adam Kaufman: 0-1 (-1.0 Unit)
- Tom Viera: 0-1 (-1.0 Unit)
